Fig. 6.

Retinal ganglion cell survival after Morrison's OHT model in the DA rat is significantly enhanced by topical treatment with CoQ10/TPGS micelles. [A] OHT model induction led to a significant decline in RGC density (and increase in nearest neighbour distance) which was not recovered by treatment with TPGS micelles alone. Daily topical administration of CoQ10/TPGS micelles resulted in a significant preservation in RGC populations (one-way ANOVA with Tukey posthoc tests, p < 0.001). On dividing the retina into a series of 15 concentric non-overlapping rings (as described in (Davis et al., 2016a)), most pronounced RGC preservation occurs in the central retina [C, D].