Figure 1. Schematic illustrating the mechanism for research data analyses.
The datasets available in Generation Scotland and Electronic Health Records (EHRs) are indicated, with numbers of participants and records. The Manhattan plot displays the results of a genome-wide association analysis (GWAS) using genotyped SNPs and EHR-derived serum urate measurements, as an example of how the datasets can be used together in genetic research by approved researchers. The single highest serum urate reading was taken for each participant, with covariates and methods for accounting for relatedness as previously described 5. The −log 10 (P-value) is plotted on the y-axis, and chromosomal location is plotted on the x-axis. The genome-wide significance threshold accounting for multiple testing (p-value < 5 x 10 -8) is indicated by a red line, while suggestive significance (p-value < 10 -5) is indicated by a blue line.