FIG. 3.
NAD protects GSNO modified human lens ALDH1A1: 100 µM (NAD1), 500 µM (NAD2), and 1 mM (NAD3) of NAD were incubated with 50 µg of ALDH1A1 for 5 min, and then 100 µM GSNO was added. After 0, 5, 10, 20, 50, 100, and 150 min, a 100-µl aliquot was withdrawn to determine enzyme activity with 2 mM NAD+ and 1 mM propionaldehyde at 340 nm for 5 min. The data are represented as percent of unmodified (control) ALDH1A1 activity. Values are mean ± SD.