Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 17;5:74. doi: 10.1186/s40478-017-0476-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 5 — Altered protein secretion profiles of Cln3 ^−/− microglia. Secreted protein levels were quantified from supernatants collected from WT and Cln3 ^−/− microglial cultures grown under basal conditions, or after stimulation with LPS. Following quantitative analysis of 59 soluble factors, 5 were found to be secreted at significantly lower levels by Cln3-deficient (Cln3 ^−/−) microglia over time in culture compared to wild type (WT) microglial cultures. These included the chemokines MIP-1-γ, MIP-2 and RANTES, the glycoprotein vWF, and the matrix metalloproteinase MMP-9