Table 2. The effect of solvent on the AT-CuAAC reaction of 1a ^a .

Entry	Solvent	Conv. 1a b	4a : 5a b
1	CH2Cl2	>99%	65 : 35
2	CHCl3	>99%	64 : 36
3	EtOAc	>99%	65 : 35
4	PhMe	>99%	76 : 24
5	DME	>99%	72 : 28
6	THF	>99%	86 : 14
7	NMP	91%	94 : 6

^a1 equiv. each 1a, 2, 3, 0.90 equiv. [Cu(MeCN)₄]·PF₆, 10 mM conc. of 1a, 80 °C.

^bDetermined by ¹H NMR analysis of the crude mixture.