Fig. 3.

Splicing factor regulators are elevated following treatment with resveratrol analogues. Changes to mRNA levels in HNDF cells in response to treatment with 5 μM resveratrol (1) or resveralogues 2–6 determined by quantitative reverse transcription PCR. a Expression of splicing factor regulatory genes (b) Isoform-specific transcripts of genes associated with senescence and/or DNA damage responses. Con = control (vehicle only). Green indicates up-regulated genes, red denotes down-regulated genes. The colour scale refers to fold-change in expression. Data are derived from duplicate testing of 3 biological replicates