Table 2.

Unitary costs (€, 2016) and parameters used in the model

Parameter	Resource consumption	Source
Prophylaxis costs
Pharmaceutical cost
Palivizumab (Synagis ®) 50 mg per vial (€)	511.66	[34]
Palivizumab (Synagis ®) 100 mg per vial (€)	849.64	[34]
Average pharmaceutical cost (EFP/mg) (€)	7.30
Average dose (mg/preterm infant) per injection	65.34
Administration cost
Average number of injections	3.88	[28]
Administration cost per injection (€)-	9.58	[36]
Hospitalization cost
Daily cost in paediatric ward (€)	641.06	[36]
Hospital length of stay (days)	6	Post-hoc analysis FLIP II study [14]
ICU related costs
Daily costs in ICU paediatric ward (€)	2,286.28	[36]
ICU length of stay (days) cost per visit	5	[14]
Emergency visit prior hospitalization cost
Daily cost of emergency ward (€)	103.95	[36]
Annual recurrent wheezing management costs
Direct cost (€)	749.57	[37]
Indirect cost (€)	498.62	[37]

EFP: ex-factory price; ICU: intensive care unit