Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 17;30(5):643–661. doi: 10.1007/s10534-017-0033-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 2 — Effect of antagonistic factors on uptake of Zn from ZnAAs in Caco-2 cells. Zinpyr-1 fluorescence intensity of Caco-2 cells. a Application of Zn uptake antagonists calcium (provided as CaCl₂) and copper (provided as CuCl₂) together with ZnCl₂ solution and ZnAAs. A significant inhibitory effect on Zn uptake from ZnCl₂ solution is seen. No significant inhibition of the uptake of Zn delivered by ZnGlu, ZnLys, ZnMet, and ZnLys/Glu/Met was observed. The uptake of ZnLys/Glu was significantly inhibited. b Co-application of Zn uptake antagonist phytic acid (PhytAc). Co-application of ZnCl₂ and phytic acid leads to significantly less increase in intracellular Zn levels compared to cell treated only with ZnCl₂ solution. No significant antagonistic effect was observed upon co-application of phytic acid and ZnGlu, ZnLys, ZnMet, ZnLys/Glu, and ZnLys/Glu/Met. Uptake of ZnLys/Glu/Met was higher in presence of phytic acid. Phytic acid was used in a molar ratio Zn:PhytAc = 1:50 (n = 10). c Co-application of Folic acid (FolAc). Significantly less Zn uptake via ZnCl₂ solution (FolAc was used with 100 μM concentration) is observed. A significant inhibitory effect on the uptake of ZnLys, ZnLys/Glu, and ZnLys/Glu/Met was observed. Only ZnGlu and ZnMet are unaffected, although ZnMet did not significantly increase intracellular Zn levels within 30 min (n.s. not significant)