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. 2017 Oct 17;16:162. doi: 10.1186/s12943-017-0729-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — HOTTIP may regulate SCLC cell proliferation in vitro and xerograft tumor growth of in vivo. a Plate and soft agar colony formation assay was used to detect the effect of HOTTIP overexpression on SCLC cell proliferation in vitro. b Plate colony formation assay were used to detect the effect of HOTTIP knockdown on SCLC cell proliferation in vitro. c Images of nude mice with xerograft tumor in each group. d Excised tumors’ image from nude mice in each group. e Volume change curve of each group measured on the indicated days. f Tumor weights of each group were determined. *, P < 0.05; **, P < 0.01