Table 1.
Mean Arterial Pressure, mmHg |
Heart Rate, beats/min |
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Stimulation | 2-wk C4 | 2-wk T2 | 12-wk C4 | 12-wk T2 | 2-wk C4 | 2-wk T2 | 12-wk C4 | 12-wk T2 |
Baseline | 100 ± 9 | 101 ± 5 | 118 ± 13 | 96 ± 10 | 409 ± 5 | 416 ± 9 | 402 ± 10 | 401 ± 7 |
100 µA | 101 ± 9 | 101 ± 5 | 117 ± 13 | 97 ± 10 | 407 ± 4 | 416 ± 9 | 401 ± 9 | 400 ± 8 |
Post 100 µA | 101 ± 9 | 101 ± 5 | 116 ± 13 | 97 ± 10 | 406 ± 4 | 417 ± 9 | 400 ± 9 | 400 ± 8 |
500 µA | 103 ± 9* | 104 ± 4 | 120 ± 14* | 104 ± 11 | 405 ± 4 | 417 ± 8 | 401 ± 9 | 402 ± 8 |
Post 500 µA | 102 ± 10 | 103 ± 5 | 117 ± 13 | 97 ± 9 | 405 ± 4 | 417 ± 8 | 400 ± 9 | 400 ± 8 |
1,000 µA | 106 ± 10* | 108 ± 4* | 123 ± 13* | 106 ± 11* | 406 ± 4 | 418 ± 8 | 403 ± 9 | 402 ± 9 |
Post 1,000 µA | 102 ± 10 | 102 ± 6 | 118 ± 14 | 93 ± 10 | 406 ± 4 | 420 ± 7 | 400 ± 9 | 401 ± 9 |
Mean arterial blood pressure was significantly increased during 500- and 1,000-µA stimulation in rats receiving stimulation at C4 and during 1,000-µA stimulation in rats receiving stimulation at T2. Heart rate was significantly increased during 1,000-µA stimulation in rats receiving HF-ES to the C4 spinal cord at 12 wk postinjury. No other statistically significant changes in cardiovascular parameters were observed during or after stimulation.
P < 0.05, significantly different from baseline, 100 µA, post 100 µA, post 500 µA, and post 1,000 µA.
P < 0.05, significantly different from T2 stimulation (2-way repeated-measures ANOVA with Holm-Sidak post hoc tests for individual comparisons).