Appendix Table A1.

Requirements of the analytics environments for medical big data

Maintain separation of primary molecular observations from the clinical interpretations of those data.

Support lossless data compression from primary molecular observations to clinically manageable subsets.

Maintain linkage of molecular observations to the laboratory methods used to generate them.

Support compact representation of clinically actionable subsets for optimal performance.

Simultaneously support human-viewable formats and machine-readable formats in order to facilitate implementation of decision support rules.

Anticipate fundamental changes in the understanding of human molecular variation.

Support both individual clinical care and discovery science.

Reproduced with permission from Masys et al.⁷