Appendix Table A2.

Desiderata for the integration of whole genome studies into clinical decision support (CDS)

CDS knowledge must have the potential to incorporate multiple genes and clinical information.

Keep CDS knowledge separate from variant classification.

CDS knowledge must have the capacity to support multiple EHR platforms with various data representations with minimal modification.

Support a large number of gene variants while simplifying the CDS knowledge to the extent possible.

Leverage current and developing CDS and genomics standards.

Support a CDS knowledge base deployed at and developed by multiple independent organizations.

Access and transmit only the genomic information necessary for CDS

Reproduced with permission from Welch et al.⁸