Figure 1.

Novel perfusion phantom. (a) A photograph of the perfusion phantom with dimensions. (b) Schematic of the perfusion phantom, which is comprised of a top and bottom chamber with an insert between them. A semi‐permeable membrane is located on the top of the insert; the insert prevents sagging of the membrane. (c) The perfusion phantom modified for LC‐MS sampling. Three 23G blunt needles (0.5‐mm long) were inserted through equally spaced 1‐mm holes at the bottom chamber. Two magnetic micro stir bars were placed inside the bottom chamber and rotated at 400 rpm during sampling. Eleven samples (0.25 ml per sample; 0.05 ml/s) were collected from the second syringe every minute after gadoteridol infusion, while the same amount of deionized water was added simultaneously using the third syringe. The first syringe was not used in this study.