Figure 4.

Schematic of image processing employed for pharmacokinetic parameter mapping in this study. First, flip angle (FA) maps were obtained. Second, DCE‐MRI images were co‐registered. Third, T1 maps were obtained. Fourth, contrast maps, voxel‐based contrast concentration at each time point, were obtained. Fifth, look‐up tables to correlate the reference (known) contrast concentrations with the measured ones were obtained. Sixth, arterial input function (AIF) was obtained. Seventh, contrast maps obtained in step 4 were corrected using the look‐up tables. Eighth, pharmacokinetic parameter maps were obtained.