Table 2.

Changes in psychological outcomes.

Variables	Mean change from baseline (95% CI)		P valuea
	Placebo (n = 47)	Chamomile (n = 46)
GAD-7b			0.0032
Week 2	2.3 (1.1 to 3.5)	0.2 (−0.4 to 0.7)	0.0047
Week 4	2.0 (0.8 to 3.2)	0.4 (−0.4 to 1.2)	0.016
Week 8	1.1 (−0.2 to 2.4)	1.2 (−0.06 to 2.5)	0.81
Week 16	0.6 (−0.7 to 1.9)	0.8 (−0.2 to 1.9)	0.84
Week 26	−0.4 (−1.2 to 0.4)	0.5 (−0.4 to 1.5)	0.55
HAM-Ab			0.27
Week 2	2.0 (0.9 to 3.1)	0.8 (0.1 to 1.4)	0.15
Week 4	2.8 (1.5 to 4.2)	1.3 (0.3 to 2.4)	0.06
Week 8	1.5 (0.1 to 2.9)	1.0 (−0.3 to 2.4)	0.42
Week 16	0.5 (−0.9 to 2.0)	0.4 (−0.7 to 1.6)	0.63
Week 26	−0.4 (−1.3 to 0.4)	0.1 (−0.9 to 1.1)	0.74
BAIb			0.089
Week 2	1.5 (−0.03 to 3.0)	0.1 (−0.8 to 1.0)	0.17
Week 4	1.4 (−0.4 to 3.1)	0.2 (−1.0 to 1.3)	0.19
Week 8	0.08 (−1.4 to 1.6)	0.6 (−1.2 to 2.4)	0.67
Week 16	−0.8 (−2.0 to 0.4)	0.7 (−0.9 to 2.4)	0.23
Week 26	−0.8 (−1.7 to 0.08)	−0.2 (−1.1 to 0.7)	0.65
PGWBIc
Anxiety			0.0094
Week 2	−2.2 (−3.7 to −0.6)	−0.7 (−1.8 to 0.4)	0.23
Week 4	−3.2 (−4.9 to −1.6)	−0.5 (−1.7 to 0.6)	0.0088
Week 8	−1.2 (−2.8 to 0.4)	−1.6 (−3.1 to −0.1)	0.94
Week 26	0.2 (−1.5 to 2.0)	−1.0 (−2.5 to 0.5)	0.39
PGWBI Global			0.013
Week 2	−5.4 (−9.8 to −0.9)	−1.6 (−4.8 to 1.6)	0.31
Week 4	−6.1 (−10.8 to −1.3)	−2.2 (−6.0 to 1.6)	0.21
Week 8	−1.6 (−6.6 to 3.3)	−6.9 (−12.1 to −1.6)	0.15
Week 26	2.7 (−2.9 to 8.4)	−3.2 (−7.9 to 1.5)	0.12

BAI: Beck Anxiety Inventory; GAD: Generalized Anxiety Disorder; HAM-A: Hamilton Anxiety Rating Scale; PGWBI: Psychological General Well-Being Index.

^aP values were calculated using the mixed-effects model.

^bGAD-7, HAM-A, BAI: Increasing scores indicates worsening anxiety.

^cAn increase in all PGWBI domains represents improvement in symptoms.