Multiomics data integration for different diet categories. (A) Network following HRS diet. Similarities (edges) within and between species, proteins, and metabolites (circles, squares, and triangles, respectively) across participants and time points, including only nodes significantly higher (red) or lower (blue) in HRS than baseline (two-sided t test; P < 0.05). (B) OPLS-DA plot of all data (features: metabolites, 5,552; proteome, 57,397; OTUs, 1,107) for baseline (blue, negative x axis) versus HRS (red, positive x axis); P = 8.3 × 10−6 (CV-ANOVA); R2Y(cum) = 0.96; Q2(cum) = 0.88. (C) OPLS-DA plot for HRS (red, negative x axis) versus LRS (green, positive x axis); P = 0.026 (CV-ANOVA); R2Y(cum) = 0.883; Q2(cum) = 0.534.