Fig. 1. (a) Schematic representing the design of a hybrid α-helix mimetic (right) and its comparison with an O-alkylated benzamide mimetic (left) and an α-helix (middle). (b) p53/hDM2 PPI with expansion on the native p53 peptide (PDB ID:; 1YCR). (c) Schematic illustrating the process of PPI inhibition with a proteomimetic. (d) Investigation of the accessible conformational space (shown as a shaded 3D object) highlighting the orientation of the side chains (shown in CPK format): side (top left) and top (bottom left) view of a 3-O-alkylated trimer; side (top right) and top (bottom right) view of a hybrid mimetic (i, i + 4 and i + 7 side chains together with residues that mimic them are shown in red, green and blue respectively).