Table 4.
Salivary BPIFA1 (μg/mL, median (IQR)), TNF-α, and IL-6 (pg/mL, median (IQR)) concentrations according to age, gender, fasting blood glucose, and BMI.
| BPIFA1 (median (IQR)) | TNF-α (median (IQR)) | IL-6 (median (IQR)) | ||||
|---|---|---|---|---|---|---|
| NDM | T2DM | NDM | T2DM | NDM | T2DM | |
| Nonelderly (<60) | 629.15 (1540.31–265.34) | 236.28 (1316.11–103.48) | 210.60 (293.03–67.12) | 157.56 (455.64–58.23) | 8.20 (14.00–3.21) | 11.40 (28.02–2.61) |
| Elderly (≥60) | 727.16 (1780.33–167.20) | 280.79 (588.73–144.02) | 67.16 (558.48–25.84) | 110.35 (390.03–68.20) | 7.84 (13.80–5.35) | 12.22 (33.57–4.52) |
| P value | P 1 = 0.804a | P 2 = 0.771a | P 1 = 0.459a | P 2 = 0.825a | P 1 = 0.881a | P 2 = 0.739a |
| Males | 607.65 (1488.18–261.78) | 285.94 (1010.52–101.88) | 253.77 (463.93–62.68) | 116.44 (328.92–49.38) | 5.47 (15.27–2.30) | 11.40 (33.57–2.95) |
| Females | 669.97 (2016.03–243.15) | 226.88 (423.01–103.47) | 97.17 (241.18–37.73) | 264.34 (759.63–110.35) | 9.44 (13.11–5.94) | 13.91 (23.43–4.20) |
| P value | P 1 = 0.917a | P 2 = 0.586a | P 1 = 0.194a | P 2 = 0.033a | P 1 = 0.569a | P 2 = 0.597a |
| Normal fasting blood glucose (<6.1 mg/dL) | 630.17 (1600.61–243.77) | 415.49 (2317.82–110.59) | 158.68 (269.21–44.5) | 127.74 (595.21–62.86) | 8.11 (13.48–4.67) | 4.27 (37.84–1.63) |
| Elevated fasting blood glucose (≥6.1 mg/dL) | 939.59 (1503.59–375.59) | 253.84 (875.29–100.94) | 621.17 (988.54–253.79) | 151.31 (393.48–60.22) | 8.31 (14.77–1.84) | 12.54 (29.81–4.43) |
| P value | P 1 = 0.707a | P 2 = 0.742a | P 1 = 0.248a | P 2 = 0.756a | P 1 = 0.784a | P 2 = 0.225a |
| Nonobese (BMI ≤ 28) | 644.57 (1635.69–348.47) | 285.94 (892.04–103.61) | 189.70 (296.21–44.5) | 145.12 (361.77–59.25) | 8.75 (13.75–4.67) | 10.00 (29.21–2.95) |
| Obese (BMI > 28) | 405.00 (765.98–99.65) | 201.29 (1598.02–82.00) | 146.09 (733.95–46.26) | 211.64 (1190.07–58.23) | 6.41 (13.33–3.14) | 12.86 (72.09–1140) |
| P value | P 1 = 0.123a | P 2 = 0.731a | P 1 = 0.838a | P 2 = 0.294a | P 1 = 0.613a | P 2 = 0.090a |
T2DM: type 2 diabetes mellitus; NDM: nondiabetes mellitus; BPIFA1: BPI fold containing family A, member 1; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6; BMI: body mass index; IQR: interquartile range.
P 1: comparison of NDM; P2: comparison of T2DM. aIndependent sample t-test.