Table 5.
Salivary BPIFA1 (μg/mL, median (IQR)), TNF-α, and IL-6 (pg/mL, median (IQR)) concentrations according to severity of periodontitis with or without T2DM.
| NDM | T2DM | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No periodontitis (G1) | Mild periodontitis (G2) | Moderate periodontitis (G3) | Severe periodontitis (G4) | No periodontitis (G5) | Mild periodontitis (G6) | Moderate periodontitis (G7) | Severe periodontitis (G8) | ||
| BPIFA1 (pg/mL) (median (IQR)) | 879.89 (1592.79–550.00) | 626.02 (713.92–387.36) | 195.08 (877.94–74.76) | 1441.96 (2342.94–375.59) | 110.00 (285.94–82.00) | 811.28 (1316.11–115.28) | 573.87 (1963.67–236.28) | 188.05 (340.13–55.81) | P 1,3 = 0.019a; P3,4 = 0.024a |
| P 5,6 = 0.042a; P5,7 = 0.005a | |||||||||
| P 6,8 = 0.021a; P7,8 = 0.002a | |||||||||
| P 1,5 = 0.001a; P4,8 = 0.001a | |||||||||
|
| |||||||||
| TNF-α (pg/mL) (median (IQR)) | 360.42 (715.93–213.74) | 96.16 (270.72–10.42) | 58.25 (188.67–10.38) | 253.79 (364.73–38.68) | 118.63 (637.59–46.44) | 116.44 (425.19–50.36) | 201.20 (580.28–110.35) | 84.07 (228.44–19.62) | P 1,2 = 0.002a; P1,3 < 0.001a |
| P 3,4 = 0.036a; P7,8 = 0.042a | |||||||||
| P 3,7 = 0.004a | |||||||||
|
| |||||||||
| IL-6 (pg/mL) (median (IQR)) | 3.74 (15.43–1.37) | 6.33 (9.61–4.98) | 9.45 (13.48–7.01) | 8.66 (44.56–5.47) | 10.00 (36.73–6.31) | 18.15 (38.15–2.61) | 15.89 (42.80–11.40) | 3.89 (5.31–2.21) | P 7,8 = 0.020a |
T2DM: type 2 diabetes mellitus; NDM: nondiabetes mellitus; BPIFA1: BPI fold containing family A, member 1; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6; BMI: body mass index. P1,2: G1 versus G2; P1,3: G1 versus G3; P1,5: G1 versus G5; P3,4: G3 versus G4; P5,6: G5 versus G6; P5,7: G5 versus G7; P6,8: G6 versus G8; P7,8: G7 versus G8; P4,8: G4 versus G8; P3,7: G3 versus G7. aAnalysis of variance (ANOVA).