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. Author manuscript; available in PMC: 2017 Oct 18.
Published in final edited form as: Cell Rep. 2017 Jun 20;19(12):2572–2585. doi: 10.1016/j.celrep.2017.05.079

Figure 6. Piezo2 channels function as low-pass filters of square pulse poke stimuli.

Figure 6

(A) Stimulus protocol (gray) and representative currents (black) from HEK293t cells transiently transfected with wild-type (left) or mutant Piezo2 (I802F, center and E2727del, right). Insets show responses to 40 Hz stimulation at an expanded timescale. (B) Representative currents of wild-type Piezo2 (black), and mutants I802F (red) and E2727del (blue) in response to a single test pulse. Currents are normalized to their peak. (C) Amplitude of the ‘last peak’ current, normalized to the amplitude of ‘first peak’ current at each stimulation frequency. Holding potential was −100 mV. All data are mean ± s.e.m. N = 9–11 cells per construct.