Table 2.

ADP EC₅₀ and Cangrelor IC₅₀ Values

	Age 0–28 Days	Age 1–10 Years	Age 11–18 Years	Adult
EC50 ± SEM, μmol/l	3.4 ± 0.3	2.9 ± 0.1	3.2 ± 0.2	3.2 ± 0.2
IC50 ± SEM,∗ nmol/l	0.83 ± 0.1	0.79 ± 0.2	0.85 ± 0.2	0.82 ± 0.3
IC50 ± SEM,† nmol/l	0.72 ± 0.3	0.68 ± 0.3	0.76 ± 0.2	0.66 ± 0.3

Values are mean ± SD. One-way analysis of variance was performed to test significance among curve fits for multiple datasets.

EC₅₀ = the concentration of a drug that gives half-maximal response; IC₅₀ = the concentration of an inhibitor where the response (or binding) is reduced by one-half.

^∗20 μmol/l of adenosine diphosphate (ADP) (p = 0.61).

^†5 μmol/l of ADP (p = 0.99).