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Schematic representation of (A) the preparation of nucleolin-binding aptamer-modified gold nanoparticles (AS1411-Au NPs) and their conjugation to core-shell Au@poly(catechin) NP to form AS1411-Au NPs/Au@PC NP nanocomposite for (B) tumor tissue imaging through monitoring Au cluster ions by laser desorption/ionization mass spectrometry.
