Skip to main content
. 2017 Sep 1;32(7):247–257. doi: 10.1089/cbr.2017.2253

FIG. 9.

FIG. 9.

Treatment of NOD/SCID mice bearing LnCap tumors with drug-LNP plus cys-DB-LNP mixtures or drug cys-DB conjugates. (A) Groups of 7–8 male NOD/SCID mice bearing LnCap tumors were treated twice a week for 4 weeks with saline (red circles), cys-DB-LNP plus Dox-LNP (orange squares) or cys-DB-LNP plus MMAE-LNP (green triangles) and relative tumor volume measured twice a week. (B) Groups of 7–8 male NOD/SCID mice bearing LnCap tumors were treated twice a week for 4 weeks with saline (red circles), cys-DB 5.0 mg/kg (orange squares), 2.5 mg/kg of MMAE-cys-DB (dark-green triangles) or 5.0 mg/kg MMAE-cys-DB (light-green triangles) and relative tumor volume measured twice a week. cys-DB, cys-diabody; LNP, lipid nanoparticle; NOD/SCID, non-obese diabetic severe combined immune deficiency.