Skip to main content
. 2017 Oct 18;12(10):e0186012. doi: 10.1371/journal.pone.0186012

Fig 1. Both low and high doses of risedronate prevent osteocyte apoptosis resulting from estrogen depletion.

Fig 1

A) Normal osteocytes (Casp-.Ot, long arrows), apoptotic osteocytes (Casp+.Ot, short arrows) and empty lacunae (E.Lac, arrow heads) shown in caspase-3 and methyl green stained section; B-D) Comparison of Casp-.Ot (B), Casp+.Ot (C) and E.Lac (D), respectively, among SHAM, OVX, OVX-LR and OVX-HR groups. *p < 0.05 versus OVX group; #p < 0.05 versus SHAM group. Numerical data are presented in supporting information (S1 Table).