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. 2017 Oct 18;12(10):e0186115. doi: 10.1371/journal.pone.0186115

Fig 2. Reciprocal increase in 5mC and decrease in 5hmC at the pregnancy-associated gene clusters in placentas of obese compared to lean mothers.

Fig 2

(A) Reciprocal increase in 5mC and decrease in 5hmC at the GH-CSH gene cluster on human chromosome 17q24. Differential DNA methylation (5mC, red) and hydroxymethylation (5hmC, blue) was evident at the human growth hormone-chorionic somatomammotropin (hGH/hCS/hPL) gene cluster between lean (LN) and obese (OB) epigenomes and this contrasted with the sharp resemblance in 5mC and 5hmC profiles outside the GH-CSH gene cluster as indicated in the rightmost panel. Marked differences in 5mC and 5hmC distributions are indicated by arrowheads. (B) Reciprocal increase in 5mC and decease in 5hmC at the PSG gene cluster on human chromosome 19q13. Genomic features are viewed as custom tracks in the UCSC genome browser. TSS, transcriptional start sites.