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. 2017 Oct 18;12(10):e0186276. doi: 10.1371/journal.pone.0186276

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© 2017 Skidmore et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — A) Prothrombin time (PT) assay to determine EC₅₀ for the compounds for coagulation. 100% represents the inhibition of clotting, determined as a PT of >120 seconds, 0% represents a normal PT clotting time for pooled human plasma (≈ 13–14 seconds). EC₅₀ Porcine Mucosal Heparin (PMH, the clinically used antihrombotic agent) = 2.74 x 10⁻¹ μg.mL^-1; EC₅₀ GSII = 5.44 x 10⁴μg.mL^-1. B) Activated partial thromboplastin time (aPTT) assay. 100% represents the inhibition of clotting, determined as a aPTT of >120 seconds, 0% represents a normal PT clotting time for pooled human plasma (≈ 35 seconds). EC₅₀ Porcine Mucosal Heparin (PMH) = 6.74 x 10⁻¹ μg.mL^-1; EC₅₀ PACS = 1.53 x 10⁴ μg.mL^-1. Data for Fig 6 are provided in supporting information in S6 Data.