Table 2. Age and sex-adjusted rates of all-cause mortality and CVD hospitalization by quartile of serum lipids.
| Quartile | p-value | ||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||
| Total cholesterol | |||||
| Median (range), mg/dL | 165 (118, 183) | 165 (184, 210) | 223 (211, 237) | 257 (238, 329) | |
| All-cause mortality | |||||
| Cases (person-years) | 341 (43,630.74) | 255 (43,449.59) | 184 (41,295.09) | 139 (41,238.03) | |
| Rate | 60.3 | 55.5 | 51.0 | 49.5 | 0.027 |
| CHD hospitalization | |||||
| Cases (person-years) | 609 (42,385.83) | 429 (42,671.84) | 306 (40,716.51) | 322 (40,637.52) | |
| Rate | 126.0 | 97.7 | 80.6 | 95.2 | <0.001 |
| Stroke hospitalization | |||||
| Cases (person-years) | 504 (42,683.04) | 388 (42,774.50) | 321 (40,668.79) | 297 (40,714.40) | |
| Rate | 98.3 | 85.0 | 84.7 | 93.9 | 0.361 |
| HDL cholesterol | |||||
| Median (range), mg/dL | 38 (27, 43) | 38 (44, 51) | 56 (52, 61) | 69 (62, 98) | |
| All-cause mortality | |||||
| Cases (person-years) | 315 (45,630.38) | 228 (42,053.36) | 191 (42,115.12) | 185 (39,814.59) | |
| Rate | 66.0 | 52.9 | 46.0 | 50.7 | <0.001 |
| CHD hospitalization | |||||
| Cases (person-years) | 633 (44,381.46) | 435 (41,240.43) | 337 (41,467.21) | 261 (39,322.61) | |
| Rate | 135.8 | 103.5 | 83.7 | 73.6 | <0.001 |
| Stroke hospitalization | |||||
| Cases (person-years) | 487 (44,749.58) | 378 (41,346.15) | 364 (41,439.38) | 281 (39,305.62) | |
| Rate | 110.8 | 90.4 | 86.3 | 71.9 | <0.001 |
| Non-HDL cholesterol | |||||
| Median (range), mg/dL | 115 (74, 131) | 115 (132, 156) | 169 (157, 183) | 204 (184, 276) | |
| All-cause mortality | |||||
| Cases (person-years) | 325 (43,768.99) | 253 (42,218.93) | 192 (42,588.25) | 149 (41,037.27) | |
| Rate | 58.0 | 55.9 | 50.0 | 52.7 | 0.154 |
| CHD hospitalization | |||||
| Cases (person-years) | 558 (42,614.69) | 420 (41,425.83) | 352 (41,964.77) | 336 (40,406.42) | |
| Rate | 117.6 | 98.0 | 88.0 | 96.4 | <0.001 |
| Stroke hospitalization | |||||
| Cases (person-years) | 477 (42,867.75) | 383 (41,571.73) | 339 (41,923.08) | 311 (40,478.17) | |
| Rate | 92.1 | 85.2 | 85.2 | 99.8 | 0.492 |
| LDL cholesterol | |||||
| Median (range), mg/dL | 88 (50, 102) | 88 (103, 124) | 135.75 (125, 148) | 166 (149, 224) | |
| All-cause mortality | |||||
| Cases (person-years) | 314 (41,816.10) | 246 (41,215.15) | 203 (43,304.18) | 156 (43,278.03) | |
| Rate | 60.9 | 56.0 | 50.4 | 49.7 | 0.015 |
| CHD hospitalization | |||||
| Cases (person-years) | 577 (40,679.63) | 397 (40,445.12) | 342 (42,666.73) | 350 (42,620.22) | |
| Rate | 128.4 | 95.6 | 83.1 | 94.4 | <0.001 |
| Stroke hospitalization | |||||
| Cases (person-years) | 460 (40,965.45) | 369 (40,527.55) | 370 (42,657.15) | 311 (42,690.59) | |
| Rate | 95.5 | 85.2 | 90.2 | 91.1 | 0.606 |
| Non-HDL minus LDL cholesterol | |||||
| Median (range), mg/dL | 16.6 (7.6, 21.0) | 16.6 (22.0, 30.0) | 35 (30.6, 40.3) | 48.25 (41.0, 93.0) | |
| All-cause mortality | |||||
| Cases (person-years) | 308 (51,216.52) | 239 (42,451.48) | 206 (38,554.97) | 166 (37,390.47) | |
| Rate | 52.6 | 52.7 | 53.8 | 58.5 | 0.319 |
| CHD hospitalization | |||||
| Cases (person-years) | 449 (50,328.06) | 431 (41,582.03) | 391 (37,851.46) | 395 (36,650.16) | |
| Rate | 85.5 | 99.8 | 102.5 | 118.1 | <0.001 |
| Stroke hospitalization | |||||
| Cases (person-years) | 448 (50,354.07) | 420 (41,656.99) | 335 (37,963.04) | 307 (36,866.61) | |
| Rate | 81.4 | 94.8 | 87.7 | 101.0 | 0.013 |
| Triglycerides | |||||
| Median (range), mg/dL | 74 (43, 91) | 74 (92, 124) | 147 (126, 176) | 232 (179, 628) | |
| All-cause mortality | |||||
| Cases (person-years) | 256 (43,230.56) | 249 (43,280.85) | 222 (42,904.17) | 192 (40,197.86) | |
| Rate | 52.8 | 53.2 | 52.0 | 59.2 | 0.347 |
| CHD hospitalization | |||||
| Cases (person-years) | 354 (42,575.48) | 400 (42,462.60) | 426 (42,111.74) | 486 (39,261.89) | |
| Rate | 80.9 | 91.6 | 99.6 | 130.7 | <0.001 |
| Stroke hospitalization | |||||
| Cases (person-years) | 355 (42,606.01) | 400 (42,519.69) | 410 (42,135.18) | 345 (39,579.85) | |
| Rate | 77.5 | 88.2 | 96.0 | 101.2 | <0.001 |
| Ratio total/HDL cholesterol | |||||
| Median (range), mg/dL | 2.96 (2.11, 3.35) | 2.96 (3.38, 4.03) | 4.42 (4.06, 4.86) | 5.58 (4.92, 8.29) | |
| All-cause mortality | |||||
| Cases (person-years) | 261 (42,536.33) | 220 (42,720.99) | 238 (42,608.40) | 200 (41,747.72) | |
| Rate | 53.8 | 49.1 | 55.9 | 58.0 | 0.276 |
| CHD hospitalization | |||||
| Cases (person-years) | 370 (41,798.70) | 392 (41,961.01) | 435 (41,806.98) | 469 (40,845.02) | |
| Rate | 87.2 | 91.8 | 102.1 | 119.8 | <0.001 |
| Stroke hospitalization | |||||
| Cases (person-years) | 386 (41,761.15) | 366 (42,108.46) | 388 (41,901.78) | 370 (41,069.34) | |
| Rate | 81.3 | 81.3 | 92.4 | 107.3 | <0.001 |
| Ratio TG/HDL cholesterol | |||||
| Median (range), mg/dL | 1.20 (0.58, 1.57) | 1.20 (1.61, 2.44) | 3.05 (2.49, 3.84) | 5.49 (3.95, 17.88) | |
| All-cause mortality | |||||
| Cases (person-years) | 229 (42,638.68) | 232 (43,056.65) | 241 (42,876.82) | 217 (41,041.30) | |
| Rate | 51.5 | 49.4 | 54.6 | 61.6 | 0.041 |
| CHD hospitalization | |||||
| Cases (person-years) | 286 (42,105.98) | 395 (42,282.16) | 466 (42,014.74) | 519 (40,008.84) | |
| Rate | 70.3 | 91.1 | 107.7 | 133.2 | <0.001 |
| Stroke hospitalization | |||||
| Cases (person-years) | 321 (42,083.52) | 409 (42,283.75) | 398 (42,119.24) | 382 (40,354.22) | |
| Rate | 73.2 | 90.2 | 92.0 | 107.3 | <0.001 |
CVD: cardiovascular disease; CHD: coronary heart disease; HDL: High density lipoprotein; LDL: low density lipoprotein
Age and sex-adjusted rates: events/10,000 person-years