Table I.
Alterations in the levels of biomarkers in rat serum at 12 weeks in the control, model and SGJPF groups.
| No. | VarID | Compound name | RT (min) | VIP | Model group | SGJPF group |
|---|---|---|---|---|---|---|
| 1 | 143 | Isoleucine | 9.87 | 1.78 | ↑a | down |
| 2 | 183 | D-Erythro-sphingosine | 10.82 | 1.76 | ↑b | down |
| 3 | 231 | L-Malic acid | 12.27 | 1.53 | ↑b | down |
| 4 | 244 | Putrescine | 12.65 | 1.49 | ↓a | up |
| 5 | 257 | Malonic acid | 12.98 | 1.52 | ↑a | down |
| 6 | 273 | 3,6-Anhydro-D-galactose | 13.48 | 1.68 | ↑b | down |
| 7 | 274 | α-Ketoglutaric acid | 13.49 | 1.98 | ↑a | downc |
| 8 | 361 | Ornithine | 17.18 | 2.04 | ↑a | downc |
| 9 | 368 | Glucose | 17.55 | 1.58 | ↓a | upc |
| 10 | 374 | Hippuric acid | 17.77 | 1.79 | ↑a | down |
| 11 | 408 | Tetrahydrocorticosterone | 19.69 | 1.93 | ↑a | down |
| 12 | 462 | Fucose | 26.98 | 1.48 | ↓a | upc |
↑, relatively high in the model group vs. control group; ↓, relatively low in the model group vs. control group; up, relatively high in the SGJPF group vs. model group; down, relatively low in the SGJPF group vs. model group.
a
P<0.01
b
P<0.05 vs. control group
c
P<0.05 vs. model group. VarID, serum screening of 469 peaks to the serial number of compound; RT, retention time of substance; VIP, variable importance projection; SGJPF, Shu Gan Jian Pi formula.