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The AKT/GSK3-β/Snail pathway was suppressed by mAbE12. A dose-dependent decrease of p-AKT was observed in the mAbE12 group. The expression of Snail was downregulated and the expression of E-cadherin was upregulated in the mAbE12 group. β-actin served as a control. AKT, protein kinase B; p-, phosphorylated; Snail, snail family transcriptional repressor 1; GSK3-β, glycogen synthase kinase 3 β; mAb, monoclonal antibody.
