Figure 4.

Silencing EDIL3 expression induces cell cycle arrest at the G₁ phase. HRECs were transfected with siEDIL3 or scramble siRNA and cell cycle distribution was analyzed using flow cytometry. Representative images of cell cycle distribution in (A) control (B) scramble and (C) siEDIL3 groups. (D) Silencing EDIL3 expression significantly increased the population of HRECs in the G₁ phase. *P<0.05, **P<0.01 vs. control and scramble groups. EDIL3, epidermal growth factor-like repeat and discoidin I-like domain-containing protein 3; HRECs, human retinal endothelial cells; si, small interfering.