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. 2017 Aug 4;16(4):4537–4544. doi: 10.3892/mmr.2017.7177

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Copyright: © Shang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Telmisartan decreases SBP and restores vascular reactivity of SHR. (A) Effects on SBP. (B) Angiotensin II levels in serum. (C) Nitric oxide concentration in serum. (D) Vascular reactivity. The results show that telmisartan decreased SBP, attenuated vascular contractility by restoring angiotensin II and nitric oxide in serum, and increased vascular relaxation. Data are presented as the mean ± standard deviation. D. ^#P<0.05, vs. WKY; *P<0.05, vs. SHR. SBP, systolic blood pressure; WKY, Wistar-Kyoto rats; SHR, spontaneously hypertensive rats.