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. 2017 Aug 4;16(4):4537–4544. doi: 10.3892/mmr.2017.7177

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Copyright: © Shang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Telmisartan decreases the levels of Smad3 and p-Smad3. (A) Expression of Smad3 was assessed by immunohistochemistry (magnification, ×200) and (B) optical density was analyzed using Image-Pro Plus 6.0. (C) Western blot analysis revealed that telmisartan effectively decreased the level of (D) Smad3, and inhibited its activation by decreasing the level of (E) p-Smad3. Data are presented as the mean ± standard deviation. ^#P<0.05, vs. WKY; *P<0.05, vs. SHR. Smad3, small mothers against decapentaplegic 3; p-Smad3, phosphorylated Smad3; WKY, Wistar-Kyoto rats; SHR, spontaneously hypertensive rats.