Table I.
Assessment of oxidative stress in blood samples and vascular tissues.
| Blood | Vascular tissue | |||||
|---|---|---|---|---|---|---|
| Group | SOD (units) | GPx (units) | MDA (nM/l) | SOD (units) | GPx (units) | MDA (nM/l) |
| WKY | 202.83±8.75 | 800.60±49.96 | 8.22±0.67 | 107.21±15.17 | 399.06±12.97 | 4.91±0.62 |
| SHR | 120.90±13.25a | 636.00±34.38a | 11.52±1.34a | 72.20±9.33a | 305.64±13.11a | 7.99±1.44a |
| Telmisartan | 195.39±22.20b | 759.40±24.27b | 7.01±0.74b | 95.00±10.33b | 384.49±13.57b | 5.56±0.70b |
Telmisartan decreased levels of MDA, and restored bioactivities of SOD and GPx in the blood and thoracic aortic vessel walls. Data are expressed as the mean ± standard deviation (n=5).
a
P<0.05, vs. WKY group
b
P<0.05, vs. SHR group. SOD, superoxide dismutase; GPx, glutathione peroxidase; MDA, malondialdehyde; WKY, Wistar-Kyoto rats; SHR, spontaneously hypertensive rats.