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. 2017 Aug 10;16(4):4569–4576. doi: 10.3892/mmr.2017.7214

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Rab5a promotes proliferation and invasion in OSCC cell lines. (A) MTT assay showed that Rab5a overexpression upregulated cell proliferation rate in FaDu cell line while Rab5a siRNA downregulated cell proliferation rate in Detroit 562 cell line. (B) Colony formation assay showed that Rab5a transfection increased while its depletion decreased colony formation ability. (C) Matrigel invasion assay showed that Rab5a overexpression promoted invading ability of FaDu cell line while its depletion inhibited invasion of Detroit 562 cells. *P<0.05 (Students' t-test). OSCC, oral squamous cell carcinoma; Rab5a, Ras-related protein Rab-5A; si, small interferring.