Figure 3.

Effect of curcumin on MMP-9 expression in the whole cortex, penumbra and core area as detected by immunohistochemistry. (A) Positive staining was visualized in brown color and indicated by white arrows. Scale bar, 100 µm. (B) Quantification of MMP-9 expression. *P<0.05, **P≤0.01 and ^#P≤0.0001, with comparisons indicated by brackets. MMP, matrix metalloproteinase; MCAO, middle cerebral artery occlusion; CUR, curcumin; CORN, corn oil (vehicle control); IOD, integrated optical density; ns, not significant.