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. 2017 Aug 4;16(4):4694–4700. doi: 10.3892/mmr.2017.7175

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — HNF1A-AS1 knockdown inhibits CRC cell migration, invasion, proliferation and colony formation in vitro. HCT116 and HT29 cells were transfected with either a HNF1A-AS1 specific siRNA or a negative control siRNA. (A) Cell proliferation was evaluated by CCK-8 assay in HCT116 cells. (B) Cell proliferation was evaluated by CCK-8 assay in HT29 cells. (C) Colony-forming assays were performed to determine the growth of CRC cells. (D) Migration ability was tested by a scratch-wound healing assay (magnification, ×100). (E) Invasion ability was tested in matrigel-coated transwell invasion chambers (magnification, ×200). *P<0.05, **P<0.01 and ***P<0.001 vs. NC. HNF1A-AS1, HNF1A antisense RNA 1; CRC, colorectal carcinoma; siRNA, small interfering RNA; CCK-8, Cell Counting Kit-8; SI, siRNA; NC, negative control.