Table IV.
Drug target prediction and analysis.
| Potential drug-target | Degree in the protein interaction network | Interaction partners in the protein interaction network (gene ID: gene symbol) |
|---|---|---|
| 10291:SF3A1 | 126 | 9939:RBM8A |
| 10987:COPS5 | 113 | 6095:RORA |
| 7520:XRCC5 | 111 | 6418:SET |
| 9611:NCoR1 | 95 | 7704:ZBTB16 |
| 2091:FBL | 85 | 3190:HNRNPK |
| 6601:SMARCC2 | 82 | 10262:SF3B4 |
| 408:ARRB1 | 79 | 1855:DVL1 |
| 6633:SNRPD2 | 79 | 10250:SRRM1 |
| 6605:SMARCE1 | 76 | 7030:TFE3 |
| 6602:SMARCD1 | 74 | 1024:CDK8 |
| 86:ACTL6A | 73 | 5469:MED1 |
| 7421:VDR | 72 | 8204:NRIP1 |
| 50813:COPS7A | 70 | 22919:MAPRE1 |
| 5705:PSMC5 | 70 | 2099:ESR1 |
The proteins with the highest degree/betweeness centrality are referred to as those with the top 5% degree/betweeness centrality in the protein interaction network. SF3A1, splicing factor 3a subunit 1; COPS5, COP9 signalosome subunit 5; XRCC5, X-ray repair cross complementing 5; NCoR1, nuclear receptor corepressor 1; FBL, fibrillarin; SMARCC2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2; ARRB1, arrestin β1; SNRPD2, small nuclear ribonucleoprotein D2 polypeptide; SMARCE1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; SMARCD1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1; ACTL6A, actin-like 6A; VDR, vitamin D receptor; COPS7A, COP9 signalosome subunit 7A; PSMC5, proteasome 26S subunit, ATPase 5.