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Effects of TGF-β1, SB203580, PD98059, SP600125 and OMT on type I and type III collagen deposition in CFBs (magnification, ×200). Cells were treated with TGF-β1 (20 ng/ml) for 24 h, with or without pretreatment with SB203580 (1×10−5 M), PD98059 (1×10−5 M), SP600125 (1×10−5 M), or different doses of OMT (L, 1.89×10−4 M; M, 3.78×10−4 M; or H, 7.56×10−4 M) for 1 h. TGF-β1, transforming growth factor-β1; OMT, oxymatrine; CFBs, cardiac fibroblasts.
