Table I.

Inhibitory effect of OMT, SB203580, PD98059 and SP600125 on TGF-β1-induced cardiac fibroblast proliferation.

Experimental group	Concentration	OD490	Rate of inhibition of cell proliferation (%)
Control	–	0.343±0.007	–
TGF-β1	20 ng/ml	0.369±0.013a	–
TGF-β1+SB203580	1×10−5 M	0.318±0.015b	13.82
TGF-β1+PD98059	1×10−5 M	0.279±0.023b	24.39
TGF-β1+SP600125	1×10−5 M	0.351±0.039	4.88
TGF-β1+OMT-L	1.89×10−4 M	0.347±0.025	5.96
TGF-β1+OMT-M	3.78×10−4 M	0.288±0.057b	21.95
TGF-β1+OMT-H	7.56×10−4 M	0.236±0.057b	36.04

Data are expressed as mean ± standard error of the mean (n=3).

^aP<0.05 vs. control

^bP<0.01 vs. TGF-β1. OMT, oxymatrine; TGF-β1, transforming growth factor-β1; OD, optical density; L, low-dose; M, medium-dose; H, high-dose.