Figure 5.

In vivo assessment of rapamycin particles in the RA model. (A) Clinical scores of Naïve mice, mice treated with empty NP and mice treated with rapamycin particles. Mice treated with rapamycin particles had lower clinical scores, compared with those in the other two groups. (B) Weights of mice. Naïve mice and mice treated with NP were used as controls, which exhibited reduced weight over time. (C) TNF, (D) IL-6 and (E) IL-10 were present in the sera of mice. *P<0.05 and **P<0.01. RA, rheumatoid arthritis; Naïve, untreated; NP, empty particles; Rapa/NP mice with RA and rapamycin particle treatment; TNF, tumor necrosis factor; IL, interleukin.