Figure 1.

Alteration frequency analysis of TMPRSS2 and ERG gene in human cancers using cBioPortal. (A) The alteration frequencies of TMPRSS2 and ERG across 148 cancer studies (min. % altered samples: 2% are presented). Gene amplification is the highest in breast cancer while gene fusion is the most frequent in prostate cancers. The red bars indicate gene amplification, blue bars are homozygous deletions, green bars are non-synonymous mutations, and gray bars indicate multiple alterations. (B) Gene fusion frequencies of TMPRSS2 and ERG in prostate cancers in four independent studies. Purple bars represent gene fusion cases of prostate cancer. TMPRSS2, transmembrane protease serine 2; ERG, v-ets erythroblastosis virus E26 oncogene homolog.