Table 2.

Infection biomarkers in baseline controls and newborns with suspected and blood culture positive early onset sepsis

				Early onset sepsis
	Time point	n (%)	Controls	Blood culture negative	Blood culture positive	P value*
White blood cells (×109/L)	t = 0	88 (97)	15.3 (8.2)	17.5 (9.7)	21.9 (82.4)	0.68
Neutrophils (×109/L)	t = 0	72 (79)	7.1 (8.5)	9.2 (7.9)	10.2 (34.1)	0.57
Platelets (×109/L)	t = 0	83 (91)	235 (82)	239 (60)	74 (164.5)	0.07
C-reactive protein (mg/dL)	t = 0t = 48–72 hDelta	75 (82)44 (48)44 (48)	<0.5 (0)N/AN/A	<0.5 (0.7)0.7 (1.8)0.1 (1.3)	0.7 (4.8)1.4 (16.3)1.7 (3.4)	0.340.810.46
Angiopoietin-1 (ng/mL)	t = 0t = 48–72 h	91 (100)49 (54)	77.4 (65.2)68.9 (44.5)	82.2 (45.7)73.6 (67.3)	28.3 (28.0)1.3 (16.1)	<0.010.02
Angiopoietin-2 (ng/mL)	t = 0t = 48–72 h	91 (100)49 (54)	10.2 (1.9)9.9 (1.5)	11.2 (6.9)11.8 (4.7)	21.1 (13.3)19.0 (18.9)	<0.010.07

Data presented as median (IQR).

^*Data analyzed with a Kruskal-Wallis test between all groups or with a Mann-Whitney test between blood culture negative and positive groups.

EOS indicates early onset sepsis; IQR, interquartile range; N/A, not applicable.