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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Neurobiol Aging. 2017 Apr 26;56:108–114. doi: 10.1016/j.neurobiolaging.2017.04.013

Table 2.

Age-Related Differences in White Matter Integrity in the Oldest-Old

FA [β (p)] MD [β (p)] AD [β (p)] RD [β (p)]
Corpus Callosum
    Genu −0.18 (0.079) 0.18 (0.085) 0.14 (0.186) 0.19 (0.068)
    Body −0.22 (0.037) 0.17 (0.117) 0.10 (0.337) 0.18 (0.083)
    Splenium −0.30 (0.004) 0.30 (0.004) 0.22 (0.037) 0.31 (0.003)
Limbic
    Fornix body −0.23 (0.032) 0.25 (0.019) 0.24 (0.021) 0.24 (0.020)
    Fornix cres −0.34 (0.001) 0.33 (0.001) 0.31 (0.003) 0.34 (0.001)
    Cingulate gyrus −0.29 (0.004) 0.04 (0.737) −0.17 (0.104) 0.13 (0.206)
    Hippocampal cingulum −0.19 (0.074) 0.16 (0.116) 0.15 (0.150) 0.17 (0.107)
Association
    External capsule −0.33 (0.001) 0.24 (0.021) 0.17 (0.119) 0.28 (0.007)
    Superior longitudinal fasciculus −0.18 (0.085) 0.16 (0.143) 0.10 (0.342) 0.17 (0.109)
    Inferior longitudinal fasciculus −0.30 (0.004) 0.24 (0.023) 0.18 (0.085) 0.26 (0.012)
    Superior fronto-occipital fasciculus −0.28 (0.009) 0.18 (0.085) 0.13 (0.207) 0.20 (0.051)
    Uncinate fasciculus −0.25 (0.015) −0.05 (0.670) −0.11 (0.291) 0.01 (0.897)
Projection/Thalamic
    Corona radiata −0.23 (0.033) 0.20 (0.054) 0.24 (0.021) 0.22 (0.043)
    Corticospinal −0.22 (0.035) 0.10 (0.360) 0.25 (0.812) 0.14 (0.184)
    Posterior thalamic radiation −0.27 (0.009) 0.23 (0.028) 0.17 (0.116) 0.26 (0.015)
    Anterior limb of internal capsule −0.24 (0.021) 0.20 (0.062) 0.15 (0.146) 0.22 (0.040)
    Posterior limb of internal capsule −0.14 (0.174) 0.32 (0.002) 0.30 (0.004) 0.30 (0.005)
    Retrolenticular part of internal capsule −0.12 (0.248) 0.28 (0.007) 0.27 (0.010) 0.28 (0.008)

Note. Significant (bolded, FDR-adjusted p < 0.012) and trending (italics, p < 0.05) relationships [β (p)] between chronological age and white matter integrity, controlling for sex and education, are presented separately for each integrity metric (FA, fractional anisotropy; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity) and each white matter region.