Skip to main content
. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Neurobiol Aging. 2017 Apr 26;56:108–114. doi: 10.1016/j.neurobiolaging.2017.04.013

Table 3.

Age-Related Differences in White Matter Integrity in the Oldest-Old Controlling for Cognitive Status

FA [β (p)] MD [β (p)] AD [β (p)] RD [β (p)]
Corpus Callosum
    Genu −0.13 (0.204) 0.15 (0.274) 0.08 (0.469) 0.13 (0.226)
    Body −0.18 (0.093) 0.13 (0.232) 0.08 (0.463) 0.14 (0.186)
    Splenium −0.27 (0.010) 0.29 (0.006) 0.23 (0.033) 0.29 (0.007)
Limbic
    Fornix body −0.17 (0.104) 0.22 (0.042) 0.22 (0.041) 0.22 (0.045)
    Fornix cres −0.29 (0.005) 0.29 (0.006) 0.27 (0.009) 0.29 (0.005)
    Cingulate gyrus −0.25 (0.017) 0.00 (0.978) −0.17 (0.114) 0.09 (0.404)
    Hippocampal cingulum −0.16 (0.128) 0.15 (0.162) 0.14 (0.204) 0.16 (0.150)
Association
    External capsule −0.30 (0.004) 0.22 (0.037) 0.16 (0.156) 0.26 (0.015)
    Superior longitudinal fasciculus −0.19 (0.075) 0.17 (0.121) 0.12 (0.291) 0.18 (0.095)
    Inferior longitudinal fasciculus −0.26 (0.013) 0.19 (0.073) 0.14 (0.200) 0.21 (0.043)
    Superior fronto-occipital fasciculus −0.26 (0.017) 0.15 (0.175) 0.10 (0.369) 0.17 (0.113)
    Uncinate fasciculus −0.24 (0.024) −0.07 (0.503) −0.13 (0.228) −0.02 (0.861)
Projection/Thalamic
    Corona radiata −0.21 (0.052) 0.16 (0.128) 0.14 (0.206) 0.18 (0.103)
    Corticospinal −0.17 (0.095) 0.10 (0.372) 0.04 (0.729) 0.13 (0.224)
    Posterior thalamic radiation −0.28 (0.011) 0.25 (0.024) 0.20 (0.074) 0.27 (0.015)
    Anterior limb of internal capsule −0.22 (0.042) 0.18 (0.101) 0.14 (0.202) 0.20 (0.072)
    Posterior limb of internal capsule −0.13 (0.225) 0.30 (0.005) 0.28 (0.009) 0.28 (0.009)
    Retrolenticular part of internal capsule −0.08 (0.429) 0.26 (0.017) 0.25 (0.018) 0.25 (0.022)

Note. Significant (bolded, FDR-adjusted p < 0.012) and trending (italics, p < 0.05) relationships [β (p)] between chronological age and white matter integrity, controlling for sex, education, and MMSE, are presented separately for each integrity metric (FA, fractional anisotropy; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity) and each white matter region. After controlling for MMSE, age-related differences in white matter integrity remained significant in the splenium of the corpus callosum, fornix cres, external capsule, posterior thalamic radiation, and posterior limb of the internal capsule.