Table 5.
Local recurrence rates and factors associated with local recurrence following IRE of hepatic primary or secondary malignancies within the current literature (key: HCC – hepatocellular carcinoma; LRFS – local recurrence free survival; BMI – body mass index; CR – complete response, PR – partial response, PD – progression of disease, SD – stable disease)
| Median Follow Up | Lesions Treated | Local Recurrence | Factors Associated with Local Recurrence | |
|---|---|---|---|---|
| MSKCC IRE (n = 77) | 26 months | Colorectal (n = 58) HCC (n = 7) Other (n = 12) |
13.4% 95% CI: (7.8 - 22.2%) |
BMI (HR 1.21, 95% CI 1.10 – 1.34; p = 0.0001) Ablation zone size (HR 1.58; 95% CI 1.12 – 2.23; p = 0.0093) |
| Niessen et al15 (n = 48) | 6 months | Colorectal (n = 16) HCC (n = 22) Other (n = 10) |
29.2% < 5cm3 – 9.7% > 5cm3 – 65% |
BMI (p = 0.022) Lesion size > 5cm (p = 0.022) Tumor pathology (p = 0.023) |
| Cannon et al16 (n = 44) | Unknown | Colorectal (n = 20) HCC (n = 14) Other (n = 10) |
(LRFS) 60% at 1 year < 3cm – 98% at 1 year |
Lesion size > 4cm (HR 3.236, 95% CI: 0.585 – 17.891) |
| Cheung et al17 (n = 18) | 18 months | HCC (n = 18) | 28% | Lesion size > 3cm (p = 0.003) |
| Hosein et al18 (n = 58) | 11 months | Colorectal (n = 58) |
36% CR 21% PR 18% PD 25% SD |
N/A |
| Eisele et al19 (n = 13) | 6 months | Colorectal (n = 6) HCC (n = 5) Other (n = 2) |
21% | Lesion size (p < 0.001) |