. Author manuscript; available in PMC: 2018 May 11.

Published in final edited form as: J Surg Oncol. 2017 May 11;115(6):704–710. doi: 10.1002/jso.24570

Table 5.

Local recurrence rates and factors associated with local recurrence following IRE of hepatic primary or secondary malignancies within the current literature (key: HCC – hepatocellular carcinoma; LRFS – local recurrence free survival; BMI – body mass index; CR – complete response, PR – partial response, PD – progression of disease, SD – stable disease)

	Median Follow Up	Lesions Treated	Local Recurrence	Factors Associated with Local Recurrence
MSKCC IRE (n = 77)	26 months	Colorectal (n = 58) HCC (n = 7) Other (n = 12)	13.4% 95% CI: (7.8 - 22.2%)	BMI (HR 1.21, 95% CI 1.10 – 1.34; p = 0.0001) Ablation zone size (HR 1.58; 95% CI 1.12 – 2.23; p = 0.0093)
Niessen et al¹⁵ (n = 48)	6 months	Colorectal (n = 16) HCC (n = 22) Other (n = 10)	29.2% < 5cm³ – 9.7% > 5cm³ – 65%	BMI (p = 0.022) Lesion size > 5cm (p = 0.022) Tumor pathology (p = 0.023)
Cannon et al¹⁶ (n = 44)	Unknown	Colorectal (n = 20) HCC (n = 14) Other (n = 10)	(LRFS) 60% at 1 year < 3cm – 98% at 1 year	Lesion size > 4cm (HR 3.236, 95% CI: 0.585 – 17.891)
Cheung et al¹⁷ (n = 18)	18 months	HCC (n = 18)	28%	Lesion size > 3cm (p = 0.003)
Hosein et al¹⁸ (n = 58)	11 months	Colorectal (n = 58)	36% CR 21% PR 18% PD 25% SD	N/A
Eisele et al¹⁹ (n = 13)	6 months	Colorectal (n = 6) HCC (n = 5) Other (n = 2)	21%	Lesion size (p < 0.001)