TABLE 1.

Characteristics of patients in three CNS risk groups

	CNS1		CNS2		CNS3		CNS1 vs. CNS2 vs CNS3	CNS1 vs. CNS2	CNS2 vs. CNS3	CNS1 vs. CNS3
Characteristic	N	%	N	%	N	%	P	P	P	P
Total	949	70.6%	217	16.1%	178	13.2%
Study
AAML03P1	257	27.1%	43	19.8%	38	21.3%	0.038	0.027	0.707	0.110
AAML0531	692	72.9%	174	80.2%	140	78.7%
Gender
Male	482	50.8%	111	51.2%	92	51.7%	0.975	0.923	0.916	0.827
Female	467	49.2%	106	48.8%	86	48.3%
Age at diagnosis (year olds)
Median (range)	9.7	(0.003–29.8)	10.5	(0.15–23.9)	8.7	(0.02–20.9)	0.096	0.470	0.050	0.054
0–1	180	19.0%	45	20.7%	55	30.9%	0.002	0.551	0.021	<0.001
1–2	51	5.4%	10	4.6%	10	5.6%	0.881	0.648	0.649	0.895
3–10	296	31.2%	57	26.3%	37	20.8%	0.012	0.154	0.203	0.005
≥11	422	44.5%	105	48.4%	76	42.7%	0.475	0.295	0.259	0.662
Cytogenetics
Normal	228	25.0%	39	19.3%	28	16.4%	0.020	0.088	0.462	0.015
t(8;21)	129	14.1%	18	8.9%	22	12.9%	0.138	0.047	0.219	0.661
inv(16)	66	7.2%	51	25.2%	32	18.7%	<0.001	<0.001	0.131	<0.001
t(9;11)/11q23	187	20.5%	43	21.3%	44	25.7%	0.306	0.798	0.312	0.124
t(6;9)	20	2.2%	3	1.5%	1	0.6%	0.330	0.784	0.628	0.230
Monosomy 7	22	2.4%	4	2.0%	5	2.9%	0.839	1.000	0.738	0.601
del(7q)	16	1.8%	1	0.5%	3	1.8%	0.415	0.337	0.337	1.000
Monosomy 5/del(5q)	11	1.2%	3	1.5%	1	0.6%	0.708	0.727	0.628	0.703
+8	67	7.3%	12	5.9%	12	7.0%	0.782	0.484	0.673	0.882
Other	167	18.3%	28	13.9%	23	13.5%	0.134	0.134	0.908	0.127
Unknown	36		15		7
FAB
M0	18	2.1%	7	3.7%	4	2.6%	0.460	0.200	0.760	0.765
M1	105	12.4%	29	15.2%	11	7.1%	0.064	0.308	0.018	0.054
M2	214	25.4%	37	19.4%	26	16.7%	0.024	0.081	0.516	0.020
M4	156	18.5%	64	33.5%	55	35.3%	<0.001	<0.001	0.733	<0.001
M5	171	20.3%	35	18.3%	46	29.5%	0.020	0.545	0.015	0.010
M6	20	2.4%	0	0.0%	1	0.6%	0.042	0.036	0.450	0.230
M7	71	8.4%	2	1.0%	4	2.6%	<0.001	<0.001	0.415	0.011
Other	89	10.5%	17	8.9%	9	5.8%	0.166	0.499	0.270	0.065
Unknown	105		26		22
Cytogenetic/molecular risk groups
Standard	538	58.4%	81	39.5%	89	50.9%	<0.001	<0.001	0.027	0.064
Low	277	30.1%	94	45.9%	65	37.1%	<0.001	<0.001	0.086	0.064
High	106	11.5%	30	14.6%	21	12.0%	0.462	0.214	0.453	0.853
Unknown	28		12		3
WBC at study entry
<10,000 µL	346	36.5%	31	14.3%	37	20.8%	<0.001	<0.001	0.089	<0.001
10,000–99,999 µL	471	49.6%	122	56.2%	88	49.4%	0.203	0.080	0.179	0.962
≥100,000 µL	132	13.9%	64	29.5%	53	29.8%	<0.001	<0.001	0.951	<0.001