TABLE 3.

Multivariable analyses for patients in three CNS groups

	OS from study entry				EFS from study entry
	N	HR	95% CI	P	HR	95% CI	P
CNS groups
CNS1	824	1			1
CNS2	183	0.85	0.63–1.15	0.288	1.29	1.02–1.63	0.035
CNS3	156	1.28	0.97–1.69	0.080	1.71	1.35–2.17	<0.001
Age
3–10 years	343	1			1
0–2 years	295	1.25	0.94–1.65	0.130	1.11	0.87–1.41	0.422
≥11 years	525	1.50	1.17–1.91	0.001	1.25	1.02–1.54	0.035
Race
White	934	1			1
Nonwhite	229	1.66	1.33–2.07	<0.001	1.31	1.06–1.60	0.011
Cytogenetic risk group
Standard	851	1			1
Low	269	0.38	0.27–0.52	<0.001	0.47	0.37–0.60	<0.001
High	43	2.34	1.61–3.39	<0.001	1.45	0.97–2.16	0.071
WBC
<100K	957	1			1
≥100K	206	1.14	0.88–1.47	0.326	1.31	1.06–1.62	0.013
Treatment
No GO	440	1			1
GO	723	0.93	0.76–1.14	0.483	0.83	0.69–0.98	0.031
	End of induction I
		RR from end induction I			TRM from end induction I
	N	HR	95% CI	P	HR	95% CI	P
CNS groups
CNS1	470	1			1
CNS2	109	1.37	0.99–1.89	0.060	1.56	0.70–3.47	0.279
CNS3	89	1.83	1.27–2.61	0.001	1.34	0.51–3.56	0.551
Age
3–10 years	196	1			1
0–2 years	160	0.94	0.65–1.35	0.733	0.78	0.19–3.20	0.729
≥11 years	312	0.91	0.68–1.22	0.518	3.92	1.52–10.1	0.005
Race
White	535	1			1
Nonwhite	133	1.23	0.91–1.66	0.172	2.04	1.02–4.06	0.043
Cytogenetic risk group
Standard	460	1			1
Low	191	0.57	0.42–0.78	<0.001	1.12	0.54–2.33	0.764
High	17	1.21	0.64–2.29	0.557	2.14	0.58–7.96	0.256
WBC
<100K	545	1			1
≥100K	123	1.43	1.05–1.95	0.024	0.27	0.07–1.10	0.067
MRD at EOI1
No	525	1			1
Yes	143	1.45	1.09–1.94	0.010	1.63	0.79–3.37	0.188
Treatment
No GO	248	1			1
GO	420	0.65	0.50–0.84	0.001	2.19	1.00–4.79	0.050
	End of induction I
		OS from end induction I			DFS from end induction I
	N	HR	95% CI	P	HR	95% CI	P
CNS groups
CNS1	470	1			1
CNS2	109	1.01	0.67–1.53	0.960	1.47	1.09–1.99	0.013
CNS3	89	1.74	1.19–2.55	0.005	1.81	1.31–2.51	<0.001
Age
3–10 years	196	1			1
0–2 years	160	1.00	0.67–1.51	0.984	0.96	0.69–1.34	0.809
≥11 years	312	1.34	0.95–1.89	0.096	1.18	0.90–1.56	0.239
Race
White	535	1			1
Nonwhite	133	1.75	1.28–2.39	<0.001	1.44	1.10–1.89	0.008
Cytogenetic risk group
Standard	460	1			1
Low	191	0.38	0.26–0.58	<0.001	0.62	0.47–0.83	0.001
High	17	1.34	0.70–2.55	0.372	1.41	0.78–2.53	0.252
WBC
<100K	545	1			1
≥100K	123	1.11	0.78–1.57	0.579	1.21	0.91–1.61	0.182
MRD at EOI1
No	525	1			1
Yes	143	1.76	1.30–2.39	<0.001	1.55	1.20–2.01	<0.001
Treatment
No GO	248	1			1
GO	420	0.81	0.61–1.08	0.149	0.76	0.60–0.95	0.018