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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Pediatr Blood Cancer. 2017 May 26;64(12):10.1002/pbc.26656. doi: 10.1002/pbc.26656

FIGURE 1.

FIGURE 1

Histological features of infant EPN. (A) Anaplastic ependymoma from an infant case demonstrating perivascular pseudorosettes, increased mitotic figures, and monomorphic round to oval nuclei with speckled chromatin (H&E, 200×). (B) Anaplastic ependymoma from a noninfant case demonstrating similar features seen in part (A) (H&E, 200×). (C) MIB-1 immunohistochemistry demonstrating elevated cell cycle activity in an infant case (MIB-1, 200×). (D) MIB-1 immunohistochemistry demonstrating elevated cell cycle activity in a noninfant case (MIB-1, 200×). (E) Immunohistochemistry for p16 in an infant case with weak expression (p16, 200×). (F) Immunohistochemistry for p16 in a noninfant case with moderate to strong expression (p16, 200×)