. Author manuscript; available in PMC: 2018 Nov 1.

Published in final edited form as: Bioorg Med Chem Lett. 2017 Sep 6;27(21):4925–4931. doi: 10.1016/j.bmcl.2017.09.003

Table 1.

Structures and activity of inhibitors 5a–h

Entry	K_i	IC₅₀^a^,^b

	(nM)
1.	13.2	22
2.	0.47	176
3.	0.46	122
4.	27.0	>1000
5.	33.3	nt
6.	13.3	nt
7.	4.21	nt
8.	9.85	>1000

Darunavir (1) exhibited K_i = 16 pM, antiviral IC₅₀ = 3 nM;

nt = not tested.